Research Opportunities

Antimicrobial Stewardship Program - Research

The SHS-UHN ASP pursues the model that all of its activities should be based on the best available evidence, should be studied to observe real-world outcomes, and should contribute to modern medical practice with knowledge translation.

Multiple research projects are active within our program.  We continue to explore new research opportunities and continue to build partnerships with key stakeholders to expand our research activities.

Our current foci of research revolve around four main areas:

  • Staphylococcus aureus bacteremia
  • Antimicrobial stewardship in intensive care units
  • Primary care antimicrobial stewardship
  • Antimicrobial stewardship in the immunocompromised host

Some recent publications from our group:

  • Bai AD, Showler A, Burry L, Steinberg M, Ricciuto DR, Fernandes T, Chiu A, Raybardhan  S, Science M, Fernando E, Tomlinson G, Bell CM, Morris AM. Comparative effectiveness of cefazolin versus cloxacillin as definitive antibiotic therapy for methicillin-susceptible Staphylococcus aureus bacteremia: results from a large multicenter cohort study. J Antimicrob Chemoth. 2015 May; 70(5):1539-46
  • Showler A, Burry L, Bai AD, Steinberg M, Ricciuto DR, Fernandes T, Chiu A, Raybardhan S, Science M, Fernando E, Bell CM, Morris AM. Use of transthoracic echocardiography in the management of low-risk Staphylococcus aureus bacteremia: results from a retrospective multicenter cohort study. J Am Coll Cardiol Img. Published online July 15, 2015. doi: 10.1016/j.jcmg.2015.02.027
  • Bai AD, Showler A, Burry L, Steinberg M, Ricciuto DR, Fernandes T, Chiu A, Raybardhan  S, Science M, Fernando E, Tomlinson G, Bell CM, Morris AM. Impact of Infectious Disease Consultation on Quality of Care, Mortality and Length of Stay in Staphylococcus aureus Bacteremia: Results from a Large Multicenter Cohort Study. Clin Infect Dis2015 May; 60(10):1451-61
  • Thampi N, Showler A, Burry L, Bai AD, Steinberg M, Ricciuto DR, Bell CM, Morris AM.    Multicenter Study of Healthcare Costs of Patients Admitted to Hospital with Staphylococcus aureus Bacteremia.  Am J Infect Control. 2015 Jul; 43(7):739-44
  • Steinberg M, Dresser LD, Daneman N, Smith OM, Matte A, Marinoff N, Bell CM, Morris AM. A National Survey of Critical Care Physicians’ Knowledge, Attitudes, and Perceptions of Antimicrobial Stewardship Programs. Journal of Intensive Care Medicine. 2014 Jul 8. {Epub ahead of print}
  • Morris AM. Antimicrobial Stewardship Programs:  Appropriate Measures and Metrics to Study their Impact. Current Treatment Options in Infectious Diseases. 2014 Jun 1;6(2):101-112.
  • Bai AD, Burry L, Showler A, Steinberg M, Ricciuto D, Fernandes T, Chiu A, Raybardhan S, Tomlinson G, Bell CM, Morris AM. Usefulness of  previous screening for methicillin-resistant Staphylococcus aureus in guiding empiric therapy for S. aureus bacteremia. Can J Infect Dis Med [in press]

Recent grant awards:

  • CIHR 2014 Operating Grant:  Knowledge to Action. Building Capacity to Improve and Sustain Antimicrobial Stewardship Programs in ICUs (ASP SUSTAIN) - $194,000 CDN.  Principal Investigators:  Lianne Jeffs, Andrew Morris.  Co-investigators:  Chaim Bell, Madelyn Law, Jonathan Mitchell, Susan Straus
  • TVN Strategic Impact Grant:  Frailty and recognizing appropriate medications in geriatrics and long-term care (FRAMING-LTC) - $596,000 CDN.  Principal Investigator:  Andrew Morris.  Co-Investigators:  Chaim Bell, Susan Bronskill, Colleen Maxwell, Lianne Jeffs
  • CAHO ARTIC Spread Project:  ARTIC Community Hospital ICU Local Leadership (CHILL) - $200,000 CDN.  Principal Investigator:  Andrew Morris.  Co-Investigators:  Chaim Bell, Linda Dresser, Yoshiko Nakamachi
  • Evaluation of a Province Wide Roll-out of Antimicrobial Stewardship Programs in Critical Care Units:  A Prospective, Stepped-wedge Observational Study. Physicians’ Services Incorporated Foundation. $81,500 CAD.  Principal Investigator:  Andrew Morris.  Co-Investigators:  Chaim Bell, Lisa Burry
  • Development of an Antimicrobial Resistance Diversity Index (ARDI) to guide initiatives and investment in public health, antimicrobial stewardship, and infection control. Canadian Institutes of Health Research (CIHR). Collaborative Health Research Projects (NSERC Partnered).  $398,681 CAD.  Principal Investigators:  Jianhong Wu, Andrew Morris.  Co-investigators:  T. Day, A. Hurford, A. McGeer, D. Patrick, G. Wright.
  • Designing an Effective Outpatient Antimicrobial Stewardship Program to Reduce Unnecessary Antibiotic Use in Primary Care Using a Mixed-Methods Collaborative Model.  MSH-UHN AMO Innovation Fund $169,695.27 CAD.  Principal Investigators:  Warren McIsaac, Andrew Morris.  Co-Investigators:  Jeff Bloom, Linda Dresser, David Tannenbaum, Lianne Jeffs, Chaim Bell, Mark McIntyre, Yoshiko Nakamachi, Rahim Moineddin

We welcome medical and pharmacy colleagues and/or trainees who have an interest in ASP research to work with our group.  If interested, please contact Marilyn Steinberg.