Sepsis (Sub-Category)

Undifferentiated Sepsis Educational Module

Dr. Lisa Burry, BScPhm PharmD FCCP FDM

Developed by:  Lisa Burry, BScPhm PharmD FCCP FDM with contributions from the CAHO ASP Project Team


  • Prompt identification and treatment of the site of infection are essential.
  • The most appropriate antimicrobial therapy should be initiated within one hour of onset of hypotension.
  • Antibiotics should be administered immediately after appropriate cultures have been obtained.  Consider empiric broad-spectrum antibiotics when a definite source of infection cannot be identified.
  • Duration of therapy will be influenced by cultures and sensitivities, as well as clinical parameters.

PDF Link to Article:

Council of Academic Hospitals of Ontario (CAHO) Antimicrobial Stewardship in the Intensive Care Unit ARTIC Project: Undifferentiated Sepsis Education Module